Walker Walking

Dollars at Work

A letter from Dr. Tak Mak

 

The 2019 Rexall™ One Walk to Conquer Cancer™ will be the event’s 17th year, marking a historic point in the journey. I remember the first Walk like it was yesterday: the passion that I saw in the Walkers’ faces as I greeted them at the finish line. I was so grateful for all their accomplishments, especially their fundraising efforts to support the work at Princess Margaret Cancer Centre. And together we have accomplished so much together – like the expansion of the first in-hospital survivorship program that is now accessible to all patients at our Cancer Centre.

Over a decade ago, my scientific discovery team and I began the long journey to find new targets and today, we now have several novel therapies that have moved into clinical trials. To accomplish this, we created a new Therapeutics Group within the Campbell Family Institute at Princess Margaret Cancer Centre. One drug, known as PLK 4, has completed Phase 1 trials and is moving into Phase 2. A second drug, known as TTK, is moving into Phase 1 trials.

In addition, another major accomplishment has been the creation of the Tumor Immunotherapy Program, supported by our Walkers. Co-Directors, Drs. Lillian Siu and Pam Ohashi, lead this work in Immunotherapy. Today, it is one of the biggest ideas of the past decade and we believe it has the potential to revolutionize cancer therapy, as the fourth pillar of cancer treatment in addition to surgery, radiation and chemotherapy. We now have over 180 active clinical trials underway, including Canada’s first gene-engineered T-cell trial. The Princess Margaret, in part to Walker community, now boasts Canada’s most comprehensive immunotherapy program. This work could be effective on a number of different types of cancer and even some of the more difficult to treat today.

As we continue on our journey, progress is being made. We understand so much more today than when I started my career in the 70’s. We are in an amazing era of genomic discovery and uncovering insights that have eluded researchers in previous decades. We now know that there are many forms of cancer, within the same type, and that some forms of one cancer are more related to another. We are discovering new cancer targets and from that, new targeted therapies.

So I encourage you to Walk in the Rexall OneWalk to Conquer Cancer to allow me and my fellow researchers to continue our work. I share your passion and your dream that one day we will conquer cancer. And while the team at Princess Margaret Cancer Centre is committed to making that dream a reality, we can’t do it alone. That’s why I hope to see you on the 2019 Walk – and don’t hesitate to introduce yourself to me!

My heartfelt thanks,
Dr. Tak Mak
Director, The Campbell Family Cancer Research Institute
Princess Margaret Cancer Centre

What is Personalized Cancer Medicine?

As one of the top 5 cancer research centres in the world, Princess Margaret Cancer Centre is leading the way in Personalized Cancer Medicine.

This approach includes using a patient’s genetic information to more precisely diagnose their cancer and tailor the most effective treatment for them.

But Personalized Cancer Medicine at The Princess Margaret is so much more. We have always focused on the individual needs of each patient and not just their disease.

That is why we have:

  • Developed award-winning clinical programs to assist our patients and their families.
  • Recruited highly-skilled physicians and scientists who have the expertise to lead important research projects and clinical studies that improve the standard of care for patients.
  • Built integrated teams that include engineers, bioinformatics specialists and medicinal chemists. These teams are translating new technology and discoveries into improved therapies that will help more patients sooner.

Our strong culture of innovation has made this cancer centre a world leader in cancer research and treatment, and with your financial support, we will lead the way in Personalized Cancer Medicine.

Dr. Mary Gospodarowicz, Medical Director

What is Personalized Cancer Medicine?

Over the past 50 years, our scientists and physicians have learned just how complex cancer is. Every patient and every patient’s cancer is unique.

There has been a clear understanding for some time that cancer is a very different disease depending on where it originates. So today lung cancer is treated in a different way than colon or kidney cancer, or leukemia.

But more recently, new technology and insight have allowed us to see that the disease is even more complex than that. There can be many forms of lung cancer or colon cancer, and a genetic analysis of a tumour may be required to confirm the specifics of each patient’s disease.

The Princess Margaret is one of the top 5 cancer research centres in the world with an outstanding reputation for breakthrough research, exemplary teaching and compassionate care.

We are three years into our Billion Dollar Challenge, which is a five-year initiative to help revolutionize cancer care. Over the next two years, The Princess Margaret will continue to be creating the blueprint, developing and implementing new procedures, and setting the gold standard for Personalized Cancer Medicine for all patients at The Princess Margaret, across Canada and around the world. In addition to genetic analysis of tumours, this new approach to cancer treatment encompasses four main themes:

  • Detect
  • Diagnose
  • Target
  • Support

Detecting cancer earlier

If cancer is detected at an early stage, the prognosis for a complete remission is much improved. Our research teams are working on many early detection initiatives, including:

  • Developing and testing better imaging equipment so small tumours can be seen more clearly.
  • Identifying unique ‘markers’ of cancers that can be detected in blood and serum tests.

Diagnosing with more precision

New equipment and procedures that determine the specific genetic mutations or changes that gave rise to a patient’s cancer are being tested at The Princess Margaret. This information will enable the experts to recommend the optimal combination of drug and other therapies for successfully treating each patient.

Targeting treatment for each patient

Improved surgical, radiation and drug treatments will target only the cancer and leave healthy tissue alone, minimizing toxic side effects. Our scientists and doctors are testing new treatments that can more effectively detect and eradicate cancer cells, leading to more durable cures.

Supporting patients and families throughout their cancer journey

Being well-informed about their disease, the treatment they will receive and the side effects that can be expected gives patients and their families more confidence, reduces anxiety and leads to improved quality of life. Our award-winning survivorship, patient education and psychosocial support programs need to be expanded so that more patients can be empowered throughout their personal cancer journey.

Immunotherapy at The Princess Margaret – Revolutionizing Cancer Therapy

Immunotherapy is rapidly gaining recognition for its potential to change the way we treat cancer and to join chemotherapy, radiation and surgery as a fourth pillar of cancer treatment.

Within the international scientific community, it has been long understood that the immune system has the ability to conquer cancer. We’re now at a point where this knowledge has started to become translated into treatment possibilities for cancer patients.

We have already seen numerous success stories of cancers fought and lives extended through immunotherapy.

This critical research is made possible in part by donations received from more than 68,000 participants over 16 years who have Walked the Walk! Because of OneWalk, we are advancing cancer research. Learn more about this revolutionary immunotherapy program at The Princess Margaret by clicking here.

To read The Princess Margaret’s Immunotherapy Magazine, click here.

immunotherapy-magazine

PRINCESS MARGARET CANCER CENTRE

Are you interested in learning about the true impact of your fundraising dollars within one of the top 5 cancer research centres in the world? Princess Margaret Cancer Centre invites you for an up-close look through its OneWalk Insider tour.

What Is The OneWalk Insider Tour?

  • A free hour-and-a-half tour and presentation that allows you to see and hear the impact that your fundraising dollars are having at The Princess Margaret.
  • The chance to view its world-class radiation centre, key researcher labs, new research tower, surgical suite and/or a clinical area of interest (pending individual tour accommodations).
  • An opportunity to hear from world-renowned doctors, researchers and radiation oncologists whose work has been directly impacted by OneWalk to Conquer Cancer.

THE ONEWALK INSIDER TOUR

HOW TO ATTEND THE ONEWALK INSIDER TOUR

Our OneWalk Insider tour is open to everyone: Walkers, potential Walkers, family, friends and donors! Tours generally run January through May on weekdays from 5-7 p.m. Select weekend dates may be available.

Open Tour Dates:

More dates coming soon!

HOST YOUR OWN ONEWALK INSIDER TOUR

Let us create a tour that suits your team and donors! Whether this is your first visit, or you’ve seen our centre before, we are happy to arrange a customized tour for you.

Book your custom tour today!

WE ARE HERE FOR YOU

Do you need more information? We are interested in speaking with you about our OneWalk Insider tour.

Contact Silva Karogaz at silva.karogaz@thepmcf.ca for any questions.

www.thepmcf.ca

What is Personalized Cancer Medicine?

At The Princess Margaret, we are excited to be leading a new integrated approach to cancer treatment called Personalized Cancer Medicine.

This approach will include using a patient’s genetic information to more precisely diagnose their cancer and provide the most effective treatment. We have always focused on the individual needs of each patient and not just their disease

But Personalized Cancer Medicine at The Princess Margaret is so much more. We have always focused on the individual needs of each patient and not just their disease.

That is why we have:

  • Developed award-winning clinical programs to assist our patients and their families.
  • Recruited highly-skilled physicians and scientists who have the expertise to lead important research projects and clinical studies that improve the standard of care for patients.
  • Built integrated teams that include engineers, bioinformatics specialists and medicinal chemists. These teams are translating new technology and discoveries into improved therapies that will help more patients sooner.

Our strong culture of innovation has made this cancer centre a world leader in cancer research and treatment, and with your financial support, we will lead the way in Personalized Cancer Medicine.

Dr. Mary Gospodarowicz, Medical Director

What is Personalized Cancer Medicine?

Over the past 50 years, our scientists and physicians have learned just how complex cancer is. Every patient and their respective cancers are unique. There has been a clear understanding that cancer is a very different disease, depending on its origination. So today, lung cancer is treated differently than colon or kidney cancer, or leukemia.

More recently, new technologies and insights have allowed us to see that the disease is even more complex as there can be many forms of the same type of cancer. A genetic analysis of a tumour may be required to confirm the specifics of each patient’s disease.

But more recently, new technology and insight have allowed us to see that the disease is even more complex than that. There can be many forms of lung cancer or colon cancer, and a genetic analysis of a tumour may be required to confirm the specifics of each patient’s disease.

We are three years into our Billion Dollar Challenge, which is a five-year initiative to help revolutionize cancer care. Over the next two years, The Princess Margaret will continue to be creating the blueprint, developing and implementing new procedures, and setting the gold standard for Personalized Cancer Medicine for all patients at The Princess Margaret, across Canada and around the world. In addition to genetic analysis of tumours, this new approach to cancer treatment encompasses four main themes:

  • Detect
  • Diagnose
  • Target
  • Support

Detecting cancer earlier

If cancer is detected at an early stage, the prognosis for a complete remission is much improved. Our research teams are working on many early detection initiatives, including:

  • Developing and testing better imaging equipment so small tumours can be seen more clearly.
  • Identifying unique ‘markers’ of cancers that can be detected in blood and serum tests.

Diagnosing with more precision

New equipment and procedures that determine the specific genetic mutations or changes, giving rise to patient cancer, are being tested at The Princess Margaret. This information will enable the experts to recommend the optimal combination of drug and other therapies for successfully treating each patient.

Targeting treatment for each patient

Improved surgical, radiation and drug treatments will target only cancerous cells, leaving healthy tissue alone while also minimizing toxic side effects. Our scientists and doctors are testing new treatments that can more effectively detect and eradicate cancer cells, leading to more durable cures.

Supporting patients and families throughout their cancer journey

Being well informed about their respective disease and the treatment they will receive, in addition to its side effects, will give patients and their families more confidence, reduce anxiety and lead to improved quality of life. Our award-winning survivorship, patient education and psychosocial support programs need to be expanded so that more patients are able to be empowered throughout their personal cancer journey.

Immunotherapy at The Princess Margaret – Revolutionizing Cancer Therapy

Immunotherapy is rapidly gaining recognition for its potential to change the way we treat cancer and to join chemotherapy, radiation and surgery as a fourth pillar of cancer treatment.

Within the international scientific community, it has been long understood that the immune system has the ability to conquer cancer. We’re now at a point where this knowledge has started to become translated into treatment possibilities for cancer patients.

We have already seen numerous success stories of cancers fought and lives extended through immunotherapy.

This critical research is made possible in part by donations received from more than 68,000 participants over 16 years who have Walked the Walk! Because of OneWalk, we are advancing cancer research. Learn more about this revolutionary immunotherapy program at The Princess Margaret by clicking here.

To read The Princess Margaret’s Immunotherapy Magazine, click here.

immunotherapy-magazine

PRINCESS MARGARET CANCER CENTRE

Are you interested in learning about the true impact of your fundraising dollars within one of the top 5 cancer research centres in the world? Princess Margaret Cancer Centre invites you for an up-close look through its OneWalk Insider tour.

What Is The OneWalk Insider Tour?

  • A free hour-and-a-half tour and presentation that allows you to see and hear the impact that your fundraising dollars are having at The Princess Margaret.
  • The chance to view its world-class radiation centre, key researcher labs, new research tower, surgical suite and/or a clinical area of interest (pending individual tour accommodations).
  • An opportunity to hear from world-renowned doctors, researchers and radiation oncologists whose work has been directly impacted by OneWalk to Conquer Cancer.

THE ONEWALK INSIDER TOUR

HOW TO ATTEND THE ONEWALK INSIDER TOUR

Our OneWalk Insider tour is open to everyone: Walkers, potential Walkers, family, friends and donors! Tours generally run January through May on weekdays from 5-7 p.m. Select weekend dates may be available.

Open Tour Dates:

More dates coming soon!

HOST YOUR OWN ONEWALK INSIDER TOUR

Let us create a tour that suits your team and donors! Whether this is your first visit, or you’ve seen our centre before, we are happy to arrange a customized tour for you.

Book your custom tour today!

WE ARE HERE FOR YOU

Do you need more information? We are interested in speaking with you about our OneWalk Insider tour.

Contact Silva Karogaz at silva.karogaz@thepmcf.ca for any questions.

www.thepmcf.ca

2018

The 16th annual OneWalk to Conquer Cancer announces $172 million raised by participants to benefit the Princess Margaret Cancer Centre.


Register for 2019
Donate

2017

Breast cancer researchers have mapped early genetic alterations in normal-looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.


Learn more

2016

Scientists at The Princess Margaret ID a biomarker that determines if colon cancer patients will benefit from treatment with cetuximab.

Learn more about cetuximab treatment

2015

The Walk becomes OneWalk to Conquer Cancer, raising funds for all cancer research. OneWalk is now one of Canada's largest cancer fundraisers.

2014

Dr. John Dick and his colleagues identify a pre-leukemic stem cell that will accelerate new therapies for acute myeloid leukemia.

2013

Walk funds support Dr. Pamela Ohashi's immunotherapy research at The Princess Margaret.

Learn more about immunotherapy

2011

Walk funds support the Conway Chemotherapy and Transfusion Centre, which now has over 70,000 patient visits annually.

2010

ELLICSR: Health, Wellness & Cancer Survivorship Centre opens on National Cancer Survivors Day.

What is ELLICSR?

2009

The Walk crosses the $100M fundraising mark and becomes North America’s #1 multi-day fundraising walk for women’s cancers.

2008

The intraoperative radiation therapy clinical trial and the development of a comprehensive digital breast imaging program is made possible.

2007

Walk funds support research on why mammographic density is a major risk factor for breast cancer.

2006

The Gattuso Rapid Diagnostic Centre opens. Seeing 1,300 patients a year, breast cancer diagnoses are completed within 24 hours.

Discover how the GRDC is saving lives

2005

Princess Margaret scientists discover that a molecule that was previously connected to Parkinson's disease is related to cancer development.

2004

Led by Dr. Tak Mak, the Campbell Family Institute for Breast Cancer Research is launched.

Discover more

2003

The first-ever Weekend to End Breast Cancer raises $12.5M to support Princess Margaret Cancer Centre.

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